What Is VDR?

VDR is a gene that encodes a protein that functions as a receptor microsoft teams for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a reduced bone mineral density among prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal position and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can serve as a repository of data and documents that are relevant to legal, business transactions, or proceedings. Access to the data, downloading, or printing is restricted. It is accessed via central computers and an extranet, which is a restricted-access Internet connection that allows users to login at set times.

VDRs are most commonly used by investment banks and companies involved in mergers and acquisitions. They need a secure platform for sharing information with investors or buyers in a way that is transparent, and the process of due diligence can require massive amounts of information. Life science companies also utilize VDRs for everything from clinical trial results to HIPAA compliance documents.